The human microbiome: defining microbiome biomarkers The microbiome, home to trillions of bacteria, fungi, and viruses, is comprised of 10-fold more cells than the human body.1 Potentially impacting the health and wellbeing of the host, these microbes directly interact with host cells and metabolic pathways. Researchers profiling the microbiome have
With over 99% mouse gene homologs in humans, mouse models provide valuable insights into the pathogenesis and treatment of human diseases like cancer, diabetes and obesity.
If you’ve attended recent conferences focused on life sciences, you might have heard the phrase “multiomics brings together all the puzzle pieces,” or something similar. More research has begun to adopt this new approach of bringing together multiple “omes” in a study to see a better picture than if you
“Crohn’s disease and Colitis collectively are inflammatory bowel diseases (IBD). These inflammatory diseases impact the gastrointestinal tract (although not exclusively gastrointestinal tract). Most of these diseases can have an autoimmune component, particularly Crohn’s disease. Crohn’s disease can affect any part of the gastrointestinal tract anywhere from the mouth to the
Carbohydrate active enzymes (CAZymes) are responsible for modification of all carbohydrates, through both anabolic and catabolic pathways. Composed of five major classes and over 300 families and subfamilies, CAZymes play a role in all carbohydrate biochemistry and are vital for the well-being of many organisms. Plant pathogens like the white-rot fungus Dichomitus squalens, for example, require a repertoire of CAZymes to invade plant cells by breaking down the cell wall¹. In humans, the gut microbiome utilizes CAZymes to breakdown complex
Drawing meaningful conclusions from microbiome experiments requires certainty in the experimental design and subsequent analysis; appropriate statistical descriptions of the microbiome are still an emerging area of inquiry. Dr. Tonya Ward, Diversigen’s Director of Data Science & Bioinformatics has worked throughout her career to identify methods to better characterize the
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